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GH deficiency places children at risk for decreased bone density and increased fracture rates. The RANKL/RANK/OPG system plays an important role in linking bone formation to bone resorption. Although OPG is thought to be secreted as a compensatory response to states of low bone density, its concentrations have not been found to differ significantly between GH-deficient, acromegalic, and healthy adults.

journal of pediatric endocrinology and metabolism

Relationships Between Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor κΒ Ligand (RANKL), and Growth Hormone (GH) Secretory Status in Short Children