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Pre-peri-menarchal diagnosis of polycystic ovary syndrome (PCOS) is important, because intervention with metformin-diet may prevent progression to full blown PCOS.

journal of pediatric endocrinology and metabolism

Insulin Resistance, Obesity, Hypofibrinolysis, Hyperandrogenism, and Coronary Heart Disease Risk Factors in 25 Pre-Perimenarchal Girls Age &lt;14 Years, 13 with Precocious Puberty, 23 with a First-degree Relative with Polycystic Ovary Syndrome