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Non-syndromic monogenic obesity is a rare cause of early-onset severe obesity in the childhood period. The aim of this study was to screen four obesity related genes ( LEP, LEPR, MC4R and POMC ) in children and adolescents who had severe, non-syndromic early onset obesity.

journal of pediatric endocrinology and metabolism

Screening of non-syndromic early-onset child and adolescent obese patients in terms of  LEP, LEPR, MC4R  and  POMC  gene variants by next-generation sequencing