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The aim of this paper is to discuss potential advances in PET kinetic models and direct reconstruction of kinetic parameters. As a prominent example we focus on a typical task in perfusion imaging and derive a system of transport-reaction-diffusion equations, which is able to include macroscopic flow properties in addition to the usual exchange between arteries, veins, and tissues. For this system we propose an inverse problem of estimating all relevant parameters from PET data. We interpret the parameter identification as a nonlinear inverse problem, for which we formulate and analyze variational regularization approaches. For the numerical solution we employ gradient-based methods and appropriate splitting methods, which are used to investigate some test cases.

Towards dynamic PET reconstruction under flow conditions: Parameter identification in a PDE model