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Salmon skin collagen peptides (SSCPs) have potential for improving physiological conditions such as early alcoholic liver injury, type 2 diabetes and hypertension. Here, we focused on the  in vitro  effects of SSCPs on vascular function. For the production of SSCPs, alcalase and papain were used to hydrolyse the skin of Atlantic salmon ( Salmo salar  L.), and their separation was made by reverse-phase high performance liquid chromatography. There were 10 low-molecular-weight peptides newly identified by mass spectrometry. In addition to five peptides previously identified, a total of 15 peptides were applied to an  in vitro  analysis of cholesterol-reducing, vasorelaxant and antithrombotic activities. The results showed that the SSCPs contained six cholesterol-lowering peptides (Ala-Pro, Leu-Gln, Asn-Val-Gly, Arg-Glu-Arg, Pro-His and Gly-Pro-Arg), two vasorelaxant peptides (Leu-Gln and Pro-His), and four antithrombotic peptides (Gly-Pro-Arg, Arg-Glu-Arg, Val-Asp-Gly-Lys and Val-Arg) as novel candidate peptides with beneficial effects on vascular function. These active peptides were also quantified. This study reveals that several peptides from salmon skin possess bifunctional properties.

Low-molecular-weight peptides with potential cardiovascular regulatory functions from Atlantic salmon skin