English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Exocyclic DNA adducts are considered as potential tools for the study of oxidative stress-related diseases, but an important aspect is their chemical reactivity towards oxidant species. We report here the oxidation of 1- N  2 -etheno-2′-deoxyguanosine (1, N  2 -εdGuo) by singlet molecular oxygen ( 1 O 2 ) generated by a non-ionic water-soluble endoperoxide [ N,N ′-di(2,3-dihydroxypropyl)-1,4-naphthalenedipropanamide endoperoxide (DHPNO 2 )] and its corresponding oxygen isotopically labeled [ 18 O]-[ N,N′ -di(2,3-dihydroxypropyl)-1,4- naphthalenedipropanamide endoperoxide (DHPN 18 O 2 )], and by photosensitization with two different photosensitizers [methylene blue (MB) and Rose Bengal (RB)]. Products detection and characterization were achieved using high performance liquid chromatography (HPLC) coupled to ultraviolet and electrospray ionization (ESI) tandem mass spectrometry, and nuclear magnetic resonance (NMR) analyses. We found that dGuo is regenerated via reaction of  1 O 2  with the ε-linkage, and we propose a dioxetane as an intermediate, which cleaves and loses the aldehyde groups as formate residues, or alternatively, it generates a 1,2-ethanediol adduct. We also report herein the quenching rate constants of  1 O 2  by 1, N  2 -εdGuo and other etheno modified nucleosides. The rate constant ( k t  ) values obtained for etheno nucleosides are comparable to the  k t   of dGuo. From these results, we suggest a possible role of  1 O 2  in the cleanup of etheno adducts by regenerating the normal base.

Oxidation of 1- N 2 -etheno-2′-deoxyguanosine by singlet molecular oxygen results in 2′-deoxyguanosine: a pathway to remove exocyclic DNA damage?