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In this study, we evaluated the antiproliferative and apoptotic properties of Pluronic-F127-containing manganese oxide nanoparticles (PF-127-coated Mn 2 O 3  NPs) derived from the leaf extract of  Glycyrrhiza uralensis  (GU) on breast adenocarcinoma, MCF7, and MDA-MB-231 cell lines. The leaf extract of GU contains bioactive molecules that act as a reducing or capping agent to form Mn 2 O 3  NPs. Various analytical techniques were used to characterize the physiochemical properties of PF-127-coated Mn 2 O 3  NPs, including spectroscopy (ultralight-Vis, Fourier transform infrared, photoluminescence), electron microscopy (field emission scanning electron microscopy and transmission electron microscopy), X-ray diffraction (XRD), electron diffracted X-ray spectroscopy (EDAX), and dynamic light scattering. The average crystallite size of Mn 2 O 3  NPs was estimated to be 80 nm, and the NPs had a cubic crystalline structure. PF127-encapsulated Mn 2 O 3  NPs significantly reduce MDA-MB-231 and MCF-7 cell proliferation, while increasing endogenous ROS and lowering mitochondrial matrix protein levels. DAPI, EtBr/AO dual staining, and Annexin-V-FITC-based flow cytometry analysis revealed that PF127-coated Mn 2 O 3  NP-treated breast cancer cells exhibit nuclear damage and apoptotic cell death, resulting in cell cycle arrest in the S phase. Furthermore, PF127-encapsulated Mn 2 O 3  NPs show strong antimicrobial efficacy against various strains. As a result, we can conclude that PF127-coated Mn 2 O 3  NPs may be effective as future anticancer agents and treatment options for breast cancer.

green processing and synthesis

In vitro  anti-cancer and antimicrobial effects of manganese oxide nanoparticles synthesized using the  Glycyrrhiza uralensis  leaf extract on breast cancer cell lines