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The emergence of drug-resistant bacteria and the lack of effective antimicrobial agents have posed a threat to public safety, so a new efficient strategy is needed to deal with the increasing severity of bacteria. Herein, a substitute antibacterial agent with high stability and biocompatibility was synthesized by incorporating lysine hydrochloride and copper sulfate pentahydrate following the liquid-phase synthesis method. The composition and structure of the Cu( ii ) complex (Lys–Cu) were characterized by performing ultraviolet-visible spectrophotometry, Fourier-transform infrared spectroscopy, X-ray diffractometry (XRD), thermogravimetric analysis-differential scanning calorimetry, and single-crystal XRD. The crystal structure of Lys–Cu belongs to a monoclinic system, space group  P 2 1 , with cell parameters of  a  = 5.14350(10),  b  = 16.8308(2),  c  = 11.4915(2) Å,  Z  = 2, and  D  = 1.548 g·cm −3 . Bacteriostatic tests were carried out on  Escherichia coli  and  Staphylococcus aureus . The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of Lys–Cu against  S. aureus  were 0.3125 and 0.9250 mg·mL −1 , respectively. The MIC and MBC values of Lys–Cu against bacterial strain  E. coli  were 0.4685 and 0.9250 mg·mL −1 , respectively.

Fabrication and characterization of lysine hydrochloride Cu( ii ) complexes and their potential for bombing bacterial resistance