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A new functional pH-responsive polyurethane-based nanomicelle has been developed with BES-Na as the functional monomer, the buffering agent with tertiary amine, and sulfonic acid group was incorporated into the hydrophilic shell as the functional agent, which resulted in polyurethane nanosystem with pH-sensitive property. Folic acid (FA) was chosen as model hydrophobic drug to evaluate the loading and pH-triggered release of the PU micelles  in vitro  drug loading and release. The drug loading content (LC) and the encapsulation efficiency (EE) for FA-loaded micelles in phosphate-buffered solutions were 7.68% and 27.72%, respectively, and the largest accumulative drug release percentages in pH 6.8 and pH 5.0 were 79.17% and 89.83% in 24 h, respectively. A facile and versatile approach has been provided for the design and fabrication of smart nanovehicles for effective drug delivery and opens a new thought in the design and fabrication of biodegradable polyurethanes for next generation of nanomicellar systems.

Functional polyurethane nanomicelle with pH-responsive drug delivery property