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Background:  Multidrug and toxin extrusion 1 (MATE1) is an organic cation/H +  exchanger, localized in the apical membrane of proximal renal tubules, which mediates the cellular elimination of organic cations into the renal lumen. These organic cations include clinically important drugs such as metformin, oxaliplatin and cimetidine. Moreover, genetic polymorphisms of  SLC47A1 , the pharmacogenetically relevant gene encoding human MATE1, have been implicated in reduced transport or accumulation to cytotoxic levels of these drugs  in vitro . However, little or no information is available on the minor allele frequency distribution of known  SLC47A1  coding SNPs in the sub-Saharan African populations.

Lack of genomic diversity in the SLC47A1 gene within the indigenous Xhosa population