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A 36-year-old primigravida woman with a normal pregnancy course presented with fetal unilateral focal ventriculomegaly on routine ultrasonography performed at 28 weeks of gestation. Periventricular venous infarction (PVI)  in utero  was diagnosed with fetal magnetic resonance imaging (MRI). The neonate was born at term uneventfully and  in utero  PVI was confirmed by MRI after birth. The neonate was diagnosed with hereditary protein C deficiency after coagulation laboratory studies. At 10 months of age, the infant presented with mild retardation of motor development. This is the first report about prenatally diagnosed PVI  in utero  by fetal MRI. When focal, unilateral enlargement of the ventricles is detected  in utero  by prenatal ultrasonography, it is important to consider PVI and perform confirmatory fetal MRI.

Prenatal diagnosis of periventricular venous infarction in utero : a case with hereditary protein C deficiency