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This work was aimed at testing gastroprotective effects of  Centaurea cyanus  L. (herba) polysaccharides (P) and polyphenols (A) fractions on stress-induced rat ulcer model. Studies evaluating acute toxicity in rats and antioxidant (chemiluminescence method) and antimicrobial (on  Staphylococcus aureus  ATCC6538 and  Escherichia coli  ATCC8739 strains) activities of  Centaurea cyanus  L. ( herba ) product, which combined polysaccharides and polyphenols fractions (PA), have also been done. Accordingly,  in vivo  pharmacological studies revealed high influence of PA product (500 mg kg -1  of body weight) on deep, moderate and superficial gastric mucosal lesions, greater than that of chemical reference, Ranitidine. P product was proven more effective than Ranitidine in opposing the emergence of deep necrotic lesions only, suggesting the ability of polysaccharides compounds to consolidate gastric mucous layer as well as their certain tendency for cooperation with polyphenols fractions. The acute toxicity study indicated the lack of toxicity of PA product and maximum tolerated doses greater than 1875 mg kg -1  of body weight. PA product provided augmented scavenger activity and week antimicrobial activity on  Staphylococcus aureus  ATCC6538 and  Escherichia coli  ATCC8739 strains, resulting in better opportunities for valorisation of the aerial part of  Centaurea cyanus  L. species in order to obtain new and effective natural medicines.

Centaurea cyanus L. Polysaccharides and Polyphenols Cooperation in Achieving Strong Rat Gastric Ulcer Protection