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No sex differeiices were observed in the prevalence of the sinking pre-beta lipoprotein. Serum mean levels of total cholesterol, triglycerides, apolipoprotein A-I and B and of the very low density total cholesterol/triglycerides ratio did not discriminate between (4-) and (—) "sinking pre-beta lipoprotein". In all the family jnembers the Lp(a) antigen was measured by rocket immunoelectrophoresis. Comparing the Lp(a) values with the behaviour of the "sinking pre-beta lipoprotein" in agarose gel electrophoresis, we demonstrated that the ability to visualize a slow moving pre-beta component, identified as the "sinking pfe«beta lipoprotein", is correlated with serum Lp(a) levels above 0.3 g/l. An inverse relationship between apolipoprotein A-I and Lp(a) values was observed (r = 0.36; p < 0.05). In spite of relatively low apolipoprotein A-I levels and high Lp(a) values, no clinical patterns of atherosclerotic diseases were found in the family inembers. The reasons for this discrepancy are discussed.

clinical chemistry and laboratory medicine

Familial Study on "Sinking pre-beta", the Lp(a) Lipoprotein, and its Relationship with Serum Lipids, Apolipoprotein A-I and B and Clinical Atherosclerosis