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A modification of the method developed by Dekirmenjian &amp; Maas (1970) Anal. Biochem. 35, 113-122) is described for the determination of 3-methoxy-4-hydroxyphenylglycol in urine. The use of 4-methoxy-3-hydroxyphenylglycol as an internal standard improves the accuracy, simplicity and reproducibility. Therefore, the method is suitable for routine determination in laboratories without gas chromatography/mass spectrometry equipment. Some results obtained in depressed patients and healthy controls are presented.

clinical chemistry and laboratory medicine

4-Methoxy-3-hydroxyphenylglycol as an Internal Standard for the Determination of 3-Methoxy-4-hydroxyphenylglycol in Urine: Results Obtained in Depressed Patients and Healthy Controls.