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: Ceruloplasmin levels were determined enzymatically and immunologically in 8 healthy men and 9 healthy women treated with 1 mcg ethinyl estradiol for 14 days. Concentrations of ceruloplasmin during estrogen administration measured by the p-phenylendiamine oxidase reaction are significantly higher than those determined by the immunological-nephelometric method, because several ceruloplasmin components, mainly C and Do, are included in the enzymatic measurement. The significant sex differences shown by the enzymatic determination can be explained by the presence of C- and D-ceruloplasmins in women, while men have almost exclusively D-ceruloplasmin. Under estrogen medication, the increase occurs primarily in the Do ceruloplasmin component, but women also show and increase in ceruloplasmin C.

Enzymatisch und immunologisch bestimmtes Coeruloplasmin: Geschlechts- und Methodenunterschiede unter Östrogeneinnahme