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Study of a protein binding method for the determination of the free urinary corticoids A protein binding method described by us for the determination of the plasma corticoids can be applied, with minor modifications, to the determination of free urinary corticoids. The lack of proportionality between the measurements on urine extracts and standard solutions, which has been described also by other authors, is apparently caused by incomplete separation of bound and free cortisol, due to nonspecific effects of the urine extract. A correction could be computed, but in practical applications the error may be ignored, if the determination method is very sensitively adjusted, and only a small amount of urine extract is used (0.05 ml). In the range of the standard curve between 0 and 10 ng, the precision of the determination is 95% or better. The lower limit of detection is 0.05 ng. The precision in the series is 5.9%. The precision from day to day is 7.6%. The recovery of various quantities of cortisol added to the urine cannot be significantly distinguished from 100%. The normal range in patients without adrenal disturbances is 15.3—83.1 §/24 h ( 35.9 /24 h, logarithmic normaldistribution). The values from patients with adrenal insufficiency, or CUSHING'S syndrome, as well as after administration of corticoids or depot ACTH, lie completely outside the normal range. Thus, this is a comparatively simple, but precise, very sensitive, and sufficiently specific method for the determination of the free urinary corticoids.

Methodische Untersuchungen zur Bestimmung der freien Harn-Corticoide mit der Proteinbindungsmethode