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Background:  Allowable total error is usually derived from data on biological variation or from state-of-the-art of measuring technology. Here we present a new principle for evaluating allowable total error when the concentration of the analyte (the measurand) is used for prediction: What are the predictive consequences of allowable total errors in terms of errors in the estimate of the hazard ratio (HR)?

Using the hazard ratio to evaluate allowable total error in predictive measurands