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Background:  Currently, multiplex ligation-dependent probe amplification (MLPA) is the most commonly used technique for the detection of large genomic rearrangements (LGRs) in the  BRCA1/2  genes. However, a very fast assay, the  BRCA1/2  multiplex amplicon quantification (MAQ), has been recently developed by Multiplicom.

Advanced tools for BRCA1/2 mutational screening: comparison between two methods for large genomic rearrangements (LGRs) detection