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An experimental setup for the determination of the photodynamic activity of dyes on the basis of scattering measurements is described. With its aid, photochemically induced morphological changes and the process of cell lysis can be registered, and action spectra measured by varying the irradiation wavelength. Different photoproducts of the photosensitizer hematoporphyrin derivative (HPD) were tested in human erythrocyte suspensions. The photodynamic activity of these products was found to depend on absorption behavior, but is lower than that of HPD.

biomedizinische technik

Einfacher Streumeßplatz zur Testung der photodynamischen Wirksamkeit von Farbstoffen. Setup for the Determination of the Photodynamic Activity of Dyes on the Basis of Scattering Measurements