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Objectives  Natural products commonly used in traditional medicine, such as essential oils (EOs), are attractive sources for the development of molecules with anti-proliferative activities for future treatment of human cancers, e.g., prostate and cervical cancer. In this study, the chemical composition of the EO from  Cymbopogon nardus  was characterized, as well as its antioxidativeproperties and anti-inflammatory and antiproliferative activities on LNCaP cells derived from prostate cancer.    Methods  The chemical composition of the EO was determined by GC/FID and GC/MS analyses. The antioxidative properties were assessed using DPPH radical scavenging assay and ABTS+• radical cation decolorization assay, and the anti-inflammatory capacity was determined by the inhibition of the lipoxygenase activity. Antiproliferative activity was evaluated by MTT assay.    Results  Collectively, our data show that the major constituents of  C. nardus  EO are citronellal (33.06 %), geraniol (28.40 %), nerol (10.94 %), elemol (5.25 %) and delta-elemene (4.09 %).  C. nardus  EO shows modest antioxidant and anti-inflammatory activity compared to the standard galic acid.  C. nardus  EO exhibits the best antiproliferative activity on the prostate cancer cell line LNCaP with an IC50 of 58.0 ± 7.9 μg/mL, acting through the induction of the cell cycle arrest.    Conclusions  This study has determined that  C. nardus  EO efficiently triggers cytotoxicity and pens a new field of investigation regarding the putative use of this EO  in vivo .

biomolecular concepts

Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of  Cymbopogon nardus , a plant used in traditional medicine