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Mevalonate pyrophosphate decarboxylase ( MPD ) is a key enzyme in terpenoid biosynthesis.  MPD  plays an important role in the upstream regulation of secondary plant metabolism. However, studies on the  MPD  gene are relatively very few despite its importance in plant metabolism. Currently, no systematic analysis has been conducted on the  MPD  gene in plants under the order Apiales, which comprises important medicinal plants such as  Panax ginseng  and  Panax notoginseng.  This study sought to explore the structural characteristics of the  MPD  gene and the effect of adaptive evolution on the gene by comparing and analyzing  MPD  gene sequences of different campanulids species. For that, phylogenetic and adaptive evolution analyses were carried out using sequences for 11  Campanulids  species.  MPD  sequence characteristics of each species were then analyzed, and the collinearity analysis of the genes was performed. As a result, a total of 21  MPD  proteins were identified in 11  Campanulids  species through BLAST analysis. Phylogenetic analysis, physical and chemical properties prediction, gene family analysis, and gene structure prediction showed that the  MPD  gene has undergone purifying selection and exhibited highly conserved structure. Analysis of physicochemical properties further showed that the  MPD  protein was a hydrophilic protein without a transmembrane region. Moreover, collinearity analysis in Apiales showed that  MPD  gene on chromosome 2 of  D. carota  and chromosome 1 of  C. sativum  were collinear. The findings showed that  MPD  gene is highly conserved. This may be a common characteristic of all essential enzymes in the biosynthesis pathways of medicinal plants. Notably,  MPD  gene is significantly affected by environmental factors which subsequently modulate its expression. The current study’s findings provide a basis for follow-up studies on  MPD  gene and key enzymes in other medicinal plants.

In silico /computational analysis of mevalonate pyrophosphate decarboxylase gene families in Campanulids