English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Evidence is presented to support the hypothesis that oleic acid and 3-(1'-oxo-7'-carboxyheptyl)-4-hydroxy-6-octyl-2-pyrone (and other 3,6-dialkyl-2-pyrones) occupy the same binding region on human sputum elastase. The mechanism of inhibition is strongly dependent on the substitution pattern of the 2-pyrone, and these mechanisms correlate with those of oleic acid and 11-undecenoic acid ("half oleic acid"). Based on the assumption that the 2-pyrone moiety and the double bond of the fatty acids bind to the same region of elastase (subsite S3), we believe that the alkyl chain points towards the S1 subsite, with the carboxylate anion fragment pointing away and probably associated with positively charged Arg217. (subsite S4 or S5).

Similar Binding Sites for Unsaturated Fatty Acids and Alkyl 2-Pyrone Inhibitors of Human Sputum Elastase