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The movement of the baby boomers into the middle ages made the 45-65 age cohort the largest and the fastest growing segment of population in the first decade of the 21st century. This demographic expansion will have multiple consequences for ageing society. This paper aimed to provide an overview on biology of midlife transition. Physical characteristics, midlife-specific morbidity and mortality were described with focus to sexual dimorphism in physique and gender gap in mortality and morbidity. These characteristics made midlife a separate and unique stage of life. In-depth knowledge of this life stage may be useful in identifying and solving problems of ageing individuals and population

On the doorstep to senility: physical changes, health status and well-being in midlife