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Summary The highly conserved proto-oncogene c-myc and tumor suppressor gene p53 in animals has been shown to play a central role in regulating multiple developmental processes including growth, proliferation and differentiation, and are also 2 of the important genes associated with programmed cell death. Using the probes corresponding to the 2 genes derived from human, we detected and localized their DNA homologs in maize (Zea mays L.) at cytogenetic level for the first time utilizing chromosome in situ hybridization. For de- tection, techniques, 3, 3'-diaminobenzidine and fluorescence staining were utilized. Both of them gave the identical results. The signals of the test probe corresponding to c-myc were detected on 4L (the long arm of chromosome 4) and 5L and 1S (the short arm of chromosome 1) simultaneously. And those of p53 were lo- calized on 5S, 1L, 3L and 9L simultaneously. These results further confirmed the existence of the homologs of the 2 genes in maize at DNA level. The improvements of FISH technique using heterologous probes were discussed.

Mammalian Apoptosis-associated Genes c-myc and p53 in Maize. Homologs and Their Locations.