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Treatment with cannabis induces a partial inactivation of the spindle apparatus, and an unequal separation of the chromosomes. There is more or less a tendency to с-mitosis at higher concentrations and to multipolar anaphases at lower concentrations like so many other narcotic substances. The MI value decreases linearly and sharply with the increase of concentrations used,i.e. cannabis had a severe mitodepressive effect. Long treatment for 24 h caused the death of all colls examined.

cytologia

Effect of cannabis (hashish) on mitosis of Allium cepa L. root tips. II. Dissolution of the chromatic material in the interphase nuclei of Allium cepa cells after long exposure times with cannabis (hashish).