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The present investigation deals with the changing profile of testosterone (T) and 5 alpha-dihydrotestosterone (DHT) concentrations in the rat submandibular gland (SMG) with age. T and DHT concentrations in SMG from male and female Wistar Rats 0 to 10 weeks of age were measured by a specific radioimmunoassay. T and DHT in male and female SMG showed lower values until 3 weeks (4.5 +/- 1.5 ng/g). However, at 4 weeks of age, T levels greatly increased, revealing 15.1 +/- 6.3 ng/g for males and 18.4 +/- 6.6 ng/g for females. And thereafter from 5 to 10 weeks of age, T concentrations in SMG were decreased to 3--5 ng/g. On the other hand, from 5 to 10 weeks of age, DHT concentrations in both males and females had a tendency to be accumulated, indicating approximately 1.5--3 times higher than T. It can be reasonably concluded that DHT began to be accumulated in SMG at the period of 4 to 5 weeks of age. Furthermore, it is suggested that the rat SMG demands androgen from approximately 4 weeks of age for growth and function.

Changes in Testosterone and Dihydrotestosterone in the Rat Submandibular Gland during Development