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The effects of abnormal thyroid function on the hypothalamo-pituitary-adrenal system were studied in 37 hyperthyroid and 16 hypothyroid patients and compared to 38 normal subjects. 1) Plasma corticotropin (ACTH), growth hormone (GH) and cortisol responses to insulin hypoglycemia (0.1 U/kg, iv) were examined. Plasma ACTH was determined by radioimmunoassay (RIA) using two antisera, one directed against the C-terminal portion of ACTH molecule, the other (NPA, 699 FRED) directed against the N-terminal portion. The mean basal ACTH levels determined by C-terminal antibody in normal, hyperthyroid and hy-

The Hypothalamo-Pituitary-Adrenal System in Thyroid Dysfunction