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After administration of tritum labeled tetragastrin into rats, the distribution of 3Htetragastrin was studied. Radioactivity was found to be highest in duodenal mucosa and it was confirmed by radioautogram. In the stomach, radioactivity was low but it located in the mucosa. We also investigated gastric acid secreting effects of tetragastrin in the duodenum. Tetragastrin stimulated the secretion of gastric acid and this gastric acid secretion that responded to tetragastrin was reduced, when the duodenum was removed in Shay rat. However, boiled extract from duodenal mucosa removed after injection of tetragastrin examined by Ghosh and Schild's method had no effect to increase gastric acid secretion. (See pp. 527-,-531)

Studies on Gastric Acid Stimulating Effect of Tetragastrin