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Hyperglycemia seen generally in diabetes can be interpreted as an adaptive reaction to the decreased utilization of glucose derived from insufficiency of insulin effects in vivo. Moreover, change of blood sugar level reflects the integrated effects of a number of factors. On the other hand, glucose intolerance after glucose load is clinically the most sensitive and relatively specific parameter for the diagnosis of diabetes mellitus. From these

Studies on the Behavior of Metabolites in Blood after Glucose Load in Diabetic Subjects