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It is generally known that there is some evidence suggesting an intimate relationship between vitamin B5 and diabetes mellitus. But almost nothing is known regarding the relationship between the action of insulin and vitamin B6. In my study on this subject, I obtained the following results. 1) The cause of the diabetic state in rats, being fed a diet over a 2to 3-month period in which vitamin B6 was eliminated, may be attributed to the disturbance of insulin utilization but not to the xanthurenic acid which is produced during the deficient period. 2) The diabetic state in rats, being fed a diet over a 9-month period, in which vitamin 13, was restricted to doses only sufficient to sustain life, is due to a lack of insulin. 3) It is conceivable that, one of the many factors contributing to the disturbance of insulin utilization has some relation with vitamin B, or the vitamin B6 enzyme, because the disturbance of insulin utilization in diabetic patients with a high plasma insulin level is often corrected by the use of PAL-PO4. Furthermore, the use of pyridoxine for the disturbance of oxydative phosphorylation in diabetics is not effective, the only effective agent being PAL-PO4, which is the co-enzyme of pyridoxine. These results clearly evidenced the intimate relationship between vitamin B, and diabetes in man. In conclusion, it is not the purpose of this report to emphasize the significance of PAL-PO4 for the treatment of some types of diabetes, but to assert that vitamin B6 is an important key for the resolution of the etiology and pathological physiology of diabetes mellitus.

The Relation of Vitamin B<SUB>6</SUB> to Insulin