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Kazuo NAKADA Ist Clinic, Dept. of Internal Medicine Wakayama Medical College (Instructed by Prof. Ryuzo Iwatsuru) BZ55 (carbutamide) has been studied in vitro and in vive as a series of the experiment on the hypoglycemic mechanism of sulfonylurea. 1) BZ55 administered to rabbit was recovered for the most part in the body fluid and the excretion of the agent to be dependent on the kidney on the fact of high concentration of acetylation of

Studies on the Hypoglycemic Mechanism of BZ55 (Carbutamide) with Reference to the Metabolism of the Drug Itself