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The writer has attempted to experiment on the possibility that the uterine function should be changed qualitatively by repeated injection of the uterine mucosa-emulsion, and has searched the aberrated product in the ear vein and in the uterine vein , and has studied not only the function or the mechanism of this aberrated substance, but the influence of the living body resulting from the aberration of the uterine function. The results are as follows: 1) By repeated injection of the uterine mucosa-emuIsion there are found in the ear vein of the injected rabbit an active substance which promotes the estrus cycle of the mice and the contrary active substance which controls the estrus cycle. The one is a steroid, soluble in organic solvent and is produced by the increase of normal "Uterine hormone." The other , is a protein of albumin fractions and is produced by the qualitative aberration of the uterine mucosa. This abnormal substance appears earliest and plentiest in the uterine vein and vanishes by the removal of the uterus of the repeatedly injected rabbit, but when the aberrated uterus is transplanted to the normal rabbit, it is proved in the blood of the transplanted one and it not influenced by the removal of another organ. As for the mechanism of the abnormal substance, it is always proved in spite of the existence of the uterus of the mice. brings on the atrophy of their uterus and makes the estrual effect of the folluculin in castrated mice decrease. 2) The uterine mucosa secreting the so aberrated product shows an atrophy histologically and causes the sterility. (Author's abstract)

STUDIES ON THE ABERRATION OF THE UTERINE FUNCTION, ESPECIALLY ON WHICH CAUSED BY REPEATED INJECTION OF THE UTERINE MUCOSA-EMULSION.