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Materials and methods. A total of 107 patients with various forms of EHP and endometrial adenocarcinoma were examined at the gynecological department of Zaporozhzhia City Clinical Hospital No. 7 and CI “Zaporizhzhia Regional Clinical Oncology Dispensary” of the ZRC. The first group included 34 patients with simple endometrial hyperplasia without atypia (SHWA) (mean age 41.60 ± 1.31 years). The second group consisted of 47 patients with complex endometrial hyperplasia without atypia (CHWA) (mean age 40.90 ± 1.34 years). Groups were divided into subgroups depending on the presence of uterine fibroids. The third group included 26 patients with endometrial adenocarcinoma (mean age 43.59 ± 1.43 years). The control group consisted of 20 healthy women. The patients underwent ultrasound examination on an apparatus “MyLab50” (“Esaote”, Italy) and video hysteroscopy (“Karl Storz”, Germany). Morphological study of tissue specimens was performed in the Pathology Department of the University Hospital of ZSMU. Serum proliferation marker Ki-67 and VEGF-А levels were determined by enzyme immunoassay using Elabscience reagents (USA).

Markers of proliferation and angiogenesis in endometrial hyperplastic processes combined with uterine fibroids