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La enfermedad quistica ovarica (COD) es una de las principales causas de falla reproductiva y de infertilidad, y constituye uno de los de los trastornos reproductivos mas frecuentes en vacas lecheras de alta produccion. El desarrollo de esta enfermedad esta asociado a un desequilibrio en el eje hipotalamico-hipofisario-gonadal en el cual factores endocrinos, entre ellos el sistema de factores de crecimiento analogos a insulina (IGF), participan en el desarrollo folicular, diferenciacion celular y la secrecion de hormonas ovaricas. Considerando al sistema IGF como un importante regulador del crecimiento y funcionalidad folicular, evaluamos la participacion de componentes del sistema IGF en el desarrollo de la COD. Las alteraciones en diferentes componentes del sistema IGF que podrian afectar al normal funcionamiento del ovario participando en el desarrollo de la COD en bovinos. SUMMARY . Participation of the IGF system in the pathogenesis of bovine cystic ovarian disease. Cystic ovarian disease (COD) is one of the most frequent reproductive disorders in dairy cows. Their development is associated with an imbalance in the hypothalamus-hypophyseal-gonadal axis in which endocrine factors, including insulin like growth factor (IGF) system, are involved in follicular development, cell differentiation and secretion ovarian hormones. Considering that the IGF system is an important regulator of the follicular growth and functionality, we have evaluated the involvement of members of the IGF system in the COD development. Alterations in different components of the IGF system could modify the normal ovarian function and participate in the development of the COD in cattle.

Participación del sistema IGF en la patogenia de la enfermedad quística bovina