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The purpose of the current study was (1) to develop a straightforward and rapid method to incorporate a dose-averaged linear energy transfer (LET  d  )-based biological effect model into a dose optimization algorithm for scanned protons; and (2) to apply a novel beam delivery strategy with increased LET  d  within the target, thereby enhancing the biological effect predicted using the selected relative biological effectiveness (RBE) model.

RBE Model-Based Biological Dose Optimization for Proton Radiobiology Studies