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Objective To evaluate the growth of low birth weight infants fed by fortified human milk (FHM) compared to human milk (HM) alone. Methods Sixty premature infants enrolled in this study and randomly assigned to have FHM and HM delivered by infusofeedpump, in parallel, non-blinded controlled trial. All patients were followed until day 30 or until discharge, whichever came first. The weight gain was recorded daily, while length and head circumference increment were recorded weekly. Results The FHM group gained more weight than the HM group (335.0+55.5 g vs. 290.6+108.4 g, p=0.000, 95%CI -170.2;-81.2), larger length increment (1.9+1.1cm vs. 1.2+0.4cm, p=0.000, 95%CI -1.37;-0.55), and larger head increment (1.87+1.1cm vs. 0.91+0.43cm, 95%CI -1.37;-0.55). A similar result was found when the group was divided into subgroup of 1000-1499 g and 15001999 g birth weight. The larger calorie intake in the FHM group was the reason for better growth. No adverse effect related to the intervention was found. Conclusion The study shows the benefit of FHM in growth of low birth weight infants, which is consistent when the group is divided into 1000-1499 g birth weight and 1500-1999 g birth weight sub groups. Better growth is achieved through higher calorie intake in the FHM group. No adverse effect is found as a consequence of intervention [Paediatr Indones 2003;43:177-185].

The efficacy of fortified human milk compared to human milk alone for the growth of low birth weight infants