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Aim:  The present study was conducted with the following aims: (i) To screen the  Salmonella  spp. isolates recovered from suspected cases of fowl typhoid for carriage of Class 1 integrons and analyze their association with antimicrobial resistance and (ii) to carry out molecular characterization and phylogenetic analysis of Class 1 integron-integrase ( intI1 ) gene.    Materials and Methods:  A total of 43  Salmonella  isolates were subjected to polymerase chain reaction (PCR) assay to determine the presence of Class1  intI1 . Differences between different serotypes in relation to their carriage of integrons and the differences between strains containing or not containing an integron and being resistant to different antimicrobials were analyzed by Fisher exact test using STATA™ (StataCorp, College Station, TX). Phylogenetic analysis was carried out using MEGA6 software.    Results:  Out of 43 isolates, 40 (93.02%) were found positive for Class 1 integrons. 35/40 (87.5%)  intI1 -positive isolates were multidrug resistance (MDR) (resistant to ≥4 antibiotics), which support the hypothesis of an association between the presence of Class 1 integrons and emerging MDR in  Salmonella . There was no significant difference among isolates resistant to different antimicrobials in Class 1 integron carrying isolates and the Class 1 integron negative isolates (p<0.05). Further, there was no significant difference among different serotypes in respect of their carriage of Class 1 integrons.    Conclusion:  It can be concluded that the high prevalence of Class 1 integrons indicates a high potential of  Salmonella  isolates for horizontal transmission of antimicrobial genes, especially among Gram-negative organisms.

Carriage of Class 1 integrons and molecular characterization of intI1 gene in multidrug-resistant Salmonella spp. isolates from broilers