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Routine prenatal diagnosis of chromosomal anomalies is based on invasive procedures, which carry a risk of approximately 1%-2% for loss of pregnancy. An alternative to these inherently invasive techniques is to isolate fetal DNA circulating in the pregnant mother's plasma. Free fetal DNA circulates in maternal plasma primarily as fragments of lengths &lt;500 bp, with a majority being &lt;300 bp. Separating these fragments by size facilitates an increase in the ratio of fetal to maternal DNA.

Microsystem for Isolation of Fetal DNA from Maternal Plasma by Preparative Size Separation