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Neonates exposed to drugs of abuse in utero can experience prenatal drug dependence leading to withdrawal symptoms and a number of other health problems (1). Early detection of exposure is critical to guide necessary treatment and improve outcomes for these children. Meconium begins to form in the digestive tract at 12–16 weeks gestation. Drugs and metabolites collect in meconium beginning at about 5 months gestation. Thus, meconium testing can identify exposure to drugs during the last 4 months of a full-term pregnancy (2).Our laboratory uses ELISA reagents (Immunalysis) to detect drugs of abuse in meconium. Poor specificity of immunoassay reagents for amphetamines is well characterized and as a result, specimens that test positive for amphetamines by immunoassay are routinely tested by a second analytical method to prevent false-positive results. Our ELISA screen for meconium has separate detection antibodies for amphetamine and methamphetamine. The ELISA cutoff for these drugs is 20 ng/g. All positive screen results are confirmed by GC-MS.We report the investigation of an unconfirmed positive amphetamine result. ELISA assay of the meconium specimen …

Cross-Reactivity of Phentermine with an Immunoassay Designed to Detect Amphetamine in a Meconium Specimen