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Background  Aberrant alternative splicing included alterations in components of the mRNA splicing machinery often occurred in colon cancer. However, the role of  SF3A1 , one key component of the mRNA splicing machinery, on colorectal cancer (CRC) risk was still not elucidated.    Method and Findings  We performed a hospital-based case-control study containing 801 CRC patients and 817 cancer-free controls to examine the association between  SF3A1  polymorphisms and CRC risk in a Chinese population. Four candidate SNPs (rs10376, rs5753073, rs2839998 and rs2074733) were selected based on bioinformatics analysis and previous findings. The results showed no significant associations between these SNPs and CRC risk ( P  > 0.05). Besides, the stratified analysis based on the smoking and alcohol use status obtained no statistically significant results.    Conclusion  Our study was the first one to investigate the association between  SF3A1  polymorphisms and CRC risk. The results suggested these four SNPs in  SF3A1  were not associated with CRC risk in a Chinese population, however, further more studies are needed to confirm our findings.

The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population