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T11 Target structure (T11TS), a membrane glycoprotein isolated from sheeperythrocytes, reverses the immune suppressed state of brain tumor inducedanimals by boosting the functional status of the immune cells. This study aimsat aiding in the design of more efficacious brain tumor therapies with T11target structure. We propose a mathematical model for brain tumor (glioma) andthe immune system interactions, which aims in designing efficacious brain tumortherapy. The model encompasses considerations of the interactive dynamics ofmacrophages, cytotoxic T lymphocytes, glioma cells, TGF-$\beta$, IFN-$\gamma$and the T11TS. The system undergoes sensitivity analysis, that determines whichstate variables are sensitive to the given parameters and the parameters areestimated from the published data. Computer simulations were used for modelverification and validation, which highlight the importance of T11 targetstructure in brain tumor therapy.

Mathematical modeling to elucidate brain tumor abrogation by immunotherapy with T11 target structure