English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective  The aim of this study was to examine the association between ectopic fat and organ-specific insulin resistance (IR) in insulin-target organs in patients with nonalcoholic fatty liver disease (NAFLD).    Methods  Organ-specific IR in the liver (hepatic glucose production (HGP)×fasting plasma insulin (FPI) and suppression of HGP by insulin [%HGP]), skeletal muscle (insulin-stimulated glucose disposal [Rd]), and adipose tissue (suppression of FFA by insulin [%FFA]) was measured in 69 patients with NAFLD using a euglycemic hyperinsulinemic clamp with tracer infusion ([6,6- 2 H 2 ]glucose). Liver fat, intramyocellular lipid (IMCL), and body composition were measured by liver biopsy, proton magnetic resonance spectroscopy, and bioelectrical impedance analysis, respectively.    Results  HGP×FPI was significantly correlated with Rd ( r  = −0.57,  P <0.001), %HGP with %FFA ( r  = 0.38,  P <0.01), and Rd with %FFA ( r  = 0.27,  P <0.05). Liver steatosis score was negatively associated with Rd ( r  = −0.47,  P <0.001) as well as with HGP×FPI ( r =  0.43,  P <0.001). Similarly, intrahepatic lipid was negatively associated with Rd ( r  = −0.32,  P <0.05). IMCL was not associated with Rd ( r  = −0.16,  P  = 0.26). Fat mass and its percentage were associated with HGP×FPI ( r =  0.50,  P <0.001;  r =  0.48,  P <0.001, respectively) and Rd ( r  = −0.59,  P <0.001;  r  = −0.52,  P <0.001, respectively), but not with %FFA ( r  = −0.21,  P  = 0.10;  r  = −0.001,  P  = 0.99, respectively).    Conclusion  Unexpectedly, fat accumulation in the skeletal muscle and adipose tissue was not associated with organ-specific IR. Instead, liver fat was associated not only with hepatic IR but also with skeletal muscle IR, suggesting a central role of fatty liver in systemic IR and that a network exists between liver and skeletal muscle.

Ectopic Fat Accumulation and Distant Organ-Specific Insulin Resistance in Japanese People with Nonalcoholic Fatty Liver Disease