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Recurrence and progression to higher grade lesions are characteristic behaviorsof gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed  IDH1  and  IDH2  statusat codon 132 of  IDH1  and codon 172 of  IDH2  by direct sequencing and anti-IDH1-R132H immunohistochemistry in 53 paired samples and their recurrences, including 29 low- grade gliomas, 16 anaplastic gliomas and 8 Glioblastomas.  IDH1/IDH2  mutation was detected in 32 primarytumors, with 25 low- grade gliomas and 6 anaplastic gliomas harboring  IDH1  mutation and 1 low- grade glioma harboring  IDH2  mutation. All of the paired tumors showed consistent  IDH1  and  IDH2  status. Patients were analyzed according to  IDH1  status and tumor-related factors. Malignant progression at recurrence was noted in 22 gliomas and was not associated with  IDH1  mutation. Survival analysis revealed patients with  IDH1  mutated gliomas had a significantly longer progression-free survival (PFS) and overall survival (OS). In conclusion, this study demonstrated a strong tendency of  IDH1/IDH2  status being consistent during progression of glioma.  IDH1  mutation was not a predictive marker for malignant progression and it was a potential prognostic marker for gliomas of Chinese patients.

Mutation Analysis of IDH1 in Paired Gliomas Revealed IDH1 Mutation Was Not Associated with Malignant Progression but Predicted Longer Survival