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Background  There is limited knowledge about atrial myocyte Ca 2+  handling in the failing hearts. The aim of this study was to examine atrial myocyte contractile function and Ca 2+  handling in rats with post-infarction heart failure (HF) and to examine whether aerobic interval training could reverse a potential dysfunction.    Methods and results  Post-infarction HF was induced in Sprague Dawley rats by ligation of the left descending coronary artery. Atrial myocyte shortening was depressed (p<0.01) and time to relaxation was prolonged (p<0.01) in sedentary HF-rats compared to healthy controls. This was associated with decreased Ca 2+  amplitude, decreased SR Ca 2+  content, and slower Ca 2+  transient decay. Atrial myocytes from HF-rats had reduced sarcoplasmic reticulum Ca 2+  ATPase activity, increased Na + /Ca 2+ -exchanger activity and increased diastolic Ca 2+  leak through ryanodine receptors. High intensity aerobic interval training in HF-rats restored atrial myocyte contractile function and reversed changes in atrial Ca 2+  handling in HF.    Conclusion  Post infarction HF in rats causes profound impairment in atrial myocyte contractile function and Ca 2+  handling. The observed dysfunction in atrial myocytes was partly reversed after aerobic interval training.

plos one

Aerobic Interval Training Partly Reverse Contractile Dysfunction and Impaired Ca2+ Handling in Atrial Myocytes from Rats with Post Infarction Heart Failure