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The relationship between circadian clocks and metabolism is intimate and complex and a number of recent studies have begun to reveal previously unknown effects of food and its temporal availability on the clock and the rhythmic transcriptome of peripheral tissues.  Nocturnin , a circadian deadenylase, is expressed rhythmically in a wide variety of tissues, but we report here that  Nocturnin  expression is arrhythmic in epididymal white adipose tissue (eWAT) of mice housed in 12∶12 LD with  ad libitum  access to food. However,  Nocturnin  expression becomes rhythmic in eWAT of mice placed on restricted feeding. We show here that  Nocturnin's  rhythmic expression pattern is not dependent upon feeding, nor is it acutely induced by feeding in the liver or eWAT of  ad libitum  fed mice. However,  Nocturnin  is acutely induced by the absence of the expected meal in eWAT of restricted fed mice. A rise in cAMP levels also induces  Nocturnin  expression, suggesting that  Nocturnin's  induction in eWAT by fasting is likely mediated through the same pathways that activate lipolysis. Therefore, this suggests that  Nocturnin  plays a role in linking nutrient sensing by the circadian clock to lipid mobilization in the adipocytes.

Nocturnin Expression Is Induced by Fasting in the White Adipose Tissue of Restricted Fed Mice