English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Vertebrate segmentation is regulated by the “segmentation clock”, which drives cyclic expression of several genes in the caudal presomitic mesoderm (PSM). One such gene is  Lunatic fringe  ( Lfng ), which encodes a modifier of Notch signalling, and which is also expressed in a stripe at the cranial end of the PSM, adjacent to the newly forming somite border. We have investigated the functional requirements for these modes of  Lfng  expression during somitogenesis by generating mice in which  Lfng  is expressed in the cranial stripe but strongly reduced in the caudal PSM, and find that requirements for  Lfng  activity alter during axial growth. Formation of cervical, thoracic and lumbar somites/vertebrae, but not sacral and adjacent tail somites/vertebrae, depends on caudal, cyclic  Lfng  expression. Indeed, the sacral region segments normally in the complete absence of  Lfng  and shows a reduced requirement for another oscillating gene,  Hes7 , indicating that the architecture of the clock alters as segmentation progresses. We present evidence that  Lfng  controls dorsal-ventral axis specification in the tail, and also suggest that  Lfng  controls the expression or activity of a long-range signal that regulates axial extension.

Differential Axial Requirements for Lunatic Fringe and Hes7 Transcription during Mouse Somitogenesis