English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The extensive use of insecticides for vector control has led to the development of insecticide resistance in  Aedes aegypti  populations on a global scale, which has significantly compromised control actions. Insecticide resistance, and its underlying mechanisms, has been investigated in several countries, mostly in South American and Asian countries. In Africa, however, studies reporting insecticide resistance are rare and data on resistance mechanisms, notably knockdown resistance ( kdr ) mutations, is scarce. In this study, the recently described V410L  kdr  mutation is reported for the first time in old world  Ae .  aegypti  populations, namely from Angola and Madeira island. Two additional  kdr  mutations, V1016I and F1534C, are also reported for the first time in populations from Angola and Cape Verde. Significant associations with the resistance phenotype were found for both V410L and V1016I individually as well as for tri-locus genotypes in the Angolan population. However, no association was found in Madeira island, probably due to the presence of a complex pattern of multiple insecticide resistance mechanisms in the local  Ae .  aegypti  population. These results suggest that populations carrying the same  kdr  mutations may respond differently to the same insecticide, stressing the need for complementary studies when assessing the impact of  kdr  resistance mechanisms in the outcome of insecticide-based control strategies.

The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa