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The NF-κB-like velvet domain protein VosA ( v iability  o f  s pores) binds to more than 1,500 promoter sequences in the filamentous fungus  Aspergillus nidulans . VosA inhibits premature induction of the developmental activator gene  brlA , which promotes asexual spore formation in response to environmental cues as light. VosA represses a novel genetic network controlled by the  sclB  gene. SclB function is antagonistic to VosA, because it induces the expression of early activator genes of asexual differentiation as  flbC  and  flbD  as well as  brlA . The SclB controlled network promotes asexual development and spore viability, but is independent of the fungal light control. SclB interactions with the RcoA transcriptional repressor subunit suggest additional inhibitory functions on transcription. SclB links asexual spore formation to the synthesis of secondary metabolites including emericellamides, austinol as well as dehydroaustinol and activates the oxidative stress response of the fungus. The fungal VosA-SclB regulatory system of transcription includes a VosA control of the  sclB  promoter, common and opposite VosA and SclB control functions of fungal development and several additional regulatory genes. The relationship between VosA and SclB illustrates the presence of a convoluted surveillance apparatus of transcriptional control, which is required for accurate fungal development and the linkage to the appropriate secondary metabolism.

plos genetics

Velvet domain protein VosA represses the zinc cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary metabolism