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The Committee Z37 of the American Standards Association was established in 1938 and charged with " the determination, establishment and promulgation of allowable concentration limits of harmful gases, vapours, fumes, dusts, and mists, and other subjects related to allowable concentration limits ofsuch substances in the atmosphere of working places from the viewpoint of occupational disease prevention". The Committee Z37 was directed by the Subcommittee on Plan and Scope under the chairmanship of Mr W. P. Yant to include in these standards: (i) the descriptive, chemical, and physical identification of the substance in question; (ii) information on the route of its absorption and its physiological and toxicological action, based on the best available information and consensus of qualified opinions; (iii) information on the methods ofsampling and determination which are satisfactory for use in conjunction with the application ofthe allowable limits to industrial situations, considering that in obtaining these data the available information on allowable concentrations is adequately determined by the particular method. Data on allowable limits should be definitely related to the type of occupational exposure to which they are applicable, such as duration ofexposure, physical activity, nature of response (whether acute or chronic), and the presence of other substances or conditions that would increase the response. Such data should be accompanied by a short treatise in which the basis of the data and their limitations should be given so that the user will know that the available information is meagre or ample for the conclusions made. When information is available on concentrations found in industrial situations or processes under conditions ofgood or poor engineering practice, these should be .used as guide for the establishment of good practice. Since the term" maximum allowable concentration" was interpreted in some instances as indicating" safe" limits or concentrations, exposure to which would exclude toxic effects on workers under any circumstances, this term was changed subsequently to "maximal acceptable concentrations" by the ASA-Z37 Editorial Subcommittee under the chairmanship of Dr H. E. Stokinger. It is now emphasized that these concentrations in themselves do

Methods used by the Committee 237 of the American Standards Association in establishing maximal acceptable concentrations of toxic dusts and gases