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Pterins, a family of heterocyclic compounds derived from 2-aminopteridin-4(1 H )-one, are widespread in living systems and participate in important biological functions, such as metabolic redox processes. Under UV-A excitation (320–400 nm), aromatic pterins (Pt) can generate reactive oxygen species (ROS), as a consequence of both energy- and electron-transfer processes from their triplet excited state. Quantum yields of singlet oxygen ( 1 O 2 ) production depend largely on the nature of the substituents on the pterin moiety and on the pH. Formation of the superoxide anion by electron transfer between the pterin radical anion and molecular oxygen leads to the production of significant amounts of hydrogen peroxide (H 2 O 2 ) by disproportionation. Dihydropterins (H 2 Pt) do not produce  1 O 2  but are oxidized by this species with high rate constants yielding pterins as well as H 2 O 2 . In contrast to aromatic derivatives, H 2 Pt are oxidized by H 2 O 2 , and rates and products strongly depend on the nature of the substituents on the H 2 Pt moiety. Aromatic pterins have been found in vivo under pathological conditions, e.g., biopterin or 6-carboxypterin are present in the skin of patients affected by vitiligo, a depigmentation disorder. The biomedical implications of the production of ROS by pterin derivatives and their reactivity with these species are discussed.

Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules